Influence of strain, sex and ovarian hormones on cannabinoid self-administration in rats
نویسندگان
چکیده
Numerous evidence indicate that Cannabis derivatives may serve as positive reinforcers in rodents, yet the hypothesis whereby genetic or gender related factors may influence drug taking behaviour has not been tested in laboratory animals. In this study we verified whether rat strain, sex and ovariectomy might be critical in the initiation, retention and extinction of the self-administration (SA) of the cannabinoid CB1 receptor agonist WIN 55,212-2 (WIN).
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